Nutritional series 1 Protein

Prioritise Protein

Prioritise Protein

Protein is a very emotional topic and there are so many biases around it these days and so many camps. Vegans, carnivores, green house emissions and much more come into play.

However the simple fact is that protein is the single most important macro for longevity. There is a lot of confusion especially in the women population around protein. Many connect protein to having big muscles. But this is not the case. Enough protein is essential for every single individual for their health and longevity!

So if you take something out this article is that you should prioritise protein by putting the protein you need in your plate always first! This is how important protein is! 

Why do we need protein?

We need protein for everything.  For turnover and but also sceleton muscle.

Proteins are always being built up and broken down within our cells. Imagine protein as the raw material, or the building blocks for our body. If we don’t eat enough protein our cell can’t do their job. Over time this can lead to problems such as hormonal imbalances, depressed immune function, poor recovery and more.

Protein is also a critical building block of bones, muscles, cartilage, skin, and blood. Hair and nails are mostly made of protein, while our body uses protein to build and repair tissues. We also use protein to make enzymes, hormones, and transporting nutrients.

Sufficient amounts of protein will 

  • Prevent muscle loss or sarcopenia.  It’s observed that muscle atrophy starts to occur even after the third decade of your life with a 30-50% decrease between ages of 40-80.  This importance of this fact cannot stated enough! As we age we need to do everything in our power to keep muscle mass. There are two things you need here. Resistance training and enough protein! This can’t be emphasised enough. Loss of muscle makes fragile and week.
  • Promote bone health and reduces risk of hip fracture. Falling and breaking bones is actually one of the biggest concerns related with aging. A higher protein intake may be more important for the aging population amongst whom it’s been found that the RDA for protein may be inadequate for maintaining skeletal muscle.

Other reasons that come into play are 

  • Increased satiety : Protein increases satiety to a greater extent than carbohydrate or fat by increasing the production of certain hormones like peptide YY and GLP-1. It also reduces ghrelin the hunger hormone for several hours.
  • Increased thermogenesis : Protein increases the thermal effect in our body, which also influences satiety and energy expenditure.

 

Summary

  • Protein is used for everything but it is especially critical for maintaining a healthy muscle mass which is increasingly difficult to maintain as we age as we lose 1% of our muscle every year we age past 40.
  • Maintaining our muscle mass is a key indicator of health and longevity. Lack of it makes fragile!!

Protein and muscle synthesis

Let’s not confuse the word muscle with a bodybuilder. Muscles is what makes as mobile and active. We need healthy muscle to be independent, have less pains and fatigue. Are we on the same page? If yes let’s move on!

Muscle is the organ of longevity and we need feed our muscles. We need to feed them protein! For a muscle to be stimulated it needs branched-chain amino acids (BCaas). These are a group of three essential amino acids: leucine, isoleucine and valine can’t be produced by your body and must be obtained from food. 

 
In particular we need Leucine in sufficient amount in order to promote maintain muscle synthesis. When I state promote muscle synthesis, this includes both growth but also maintenance of our muscles.
 
As we age it gets more difficult to trigger muscle synthesis. This is called Anabolic resistance. This means our body becomes less sensitive to stimulate muscle synthesis from the needed BCaas.

Protein need per meal

In order to stimulate enough protein synthesis we need to get around 2.5grams of leucine in one meal. Imagine your muscles like car. You need some sort of key to be able to turn it on right? Enough leucine is the key for your muscles!

How does this translate into actual food?

Animal Protein

  • We need about 30 grams of animal protein to trigger stimulus protein synthesis. 
  • For every 120grams of animal source we eat, we get around 30grams of protein. This includes beef, pork, chicken etc.
  • The amount of protein contained in fish is slightly less, so we would need about 150grams of fish to the the needed protein.
  • Organ meats contain less protein on average.

Plant Protein

  • Plant proteins are a lot less absorbable so eat need more than the actual numbers stated.
  • Plant proteins are not complete, which means they don’t contain all the needed amino-acids. That is why rice is usually combined with beans.
  • Assuming 100% absorption you need around 250grams of beans to get 30 grams of protein.

The issue as seen from the graphs above is the in order to get sufficient amount of proteins you need to consume an amount of plant protein that is far from optimal, since it will lead to an increased carb intake probably past the point one can tolerate. This will lead to overeating, more calories not to mention bloating and feeling stuffed.

You might think you can get away from not having enough protein. But this is not the case. Of course when you are young  or growing one can manage and get away with more but this will catch-up with you eventually. That is why most vegans find it difficult to maintain their lifestyle as they age. Other issues that are related to lower protein intake are bone density, teeth issues and more. Having said that there is ongoing research if our own microbiome can create BCaas but that is just a theory for now.

Fact is that animal and plant proteins are not equal as they are needed in different amounts and as they don’t have the needed Amino-acids in the correct amounts. Just think of it this way. Plants make the right amount of protein for plants, but don’t have muscles!

Protein isolates

  • I generally do not suggest having protein shakes as the body requires the full range of amino-acids for optimal function. 

Summary

  • Animal and plant proteins are needed in different amounts as plants they don’t have the needed Amino-acids in the correct amounts.
  • We need minimum 30grams of protein per meal.

Protein, cancer and mTor

You probably heard that higher amounts of protein are associated with an increased risk of cancer. This is actually not because of protein itself but of a compound called mTOR. The mechanistic target of rapamycin (mTOR) is a kinase that in humans is encoded by the MTOR gene is a potent growth stimulator.

mTOR regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. but also promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. What all this means is that in the presence of mTOR we are having the growth switch ON, which also increases the risk of cancer.

But here is the interesting point. mTOR exists in every single cell. It exists in the muscles and it is sensitive to amino-acids, but is also exists in the liver and pancreas and is sensitive to insulin and carbs!

What does that mean?

Summary

  • Protein does not increase the risk of disease or cancer.
  • We don’t want to have the mTOR switch ON all the time especially in the liver and pancreas.
  • mTOR is essential for muscle growth and less then 30gr of protein will not stimulate mTOR enough especially as we age.

Total Protein intake and meal timing

Here comes the really interesting part. Is protein intake relevant if you are doing intermittent fasting?

We know that it takes some time for the gut the relax and reset, and now that we want to trigger muscle synthesis but also that we don’t want to overstimulate mTOR and the growth stimulus. The basis is we don’t want to eat many small meals with carbs as we stimulate mTOR in the liver and we need to give a chance to our body to reset mTOR which takes 4-5 hours.

So how often should we then eat? 

  • Eating 2-3 times a meal is ideal to get all the protein you need in an 8-hour window. 
  • OMAD (one meal a day) is probably not ideal as we age as we can’t get enough protein in one meal

So how much protein do we want to eat in a day? The Recommended Daily Allowance for protein is 0.8 g/kg but that is not sufficient but also very simplistic as we have already seen so far.

On the other hand excess protein does not translate to more muscle syntheses as some of it will be turned into sugar. Also excess protein, although not associated with kidney issues I don’t see a need to overload the kidney.

So what is the sweet spot?

We shoulda aim for anywhere between 1.5 to 2 grams of protein per kilogram of ideal body weight depending on your goals and age.

Key Takeaways

I trust it is now clear why we need to prioritise protein by putting the protein we need in our plate always first! 

  • Sufficient amount of protein is required for optimal health.
  • You need minimum 30grams of protein per meal to trigger muscle synthesis.
  • All animal protein provides the essential amino-acids where-as plant protein needs to be combined.
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